Unique ionization modes
Seize maximum information with IONICON's unique ion-chemistry
IONICON is world-renowned for manufacturing PTR-TOFMS instruments with controllable and well-defined ion-chemistry (see patents EP3309817B1, US10074531B2). Particularly in the field of ENDS analysis this is a crucial requirement.
In all of our PTR-TOFMS instruments, i.e. even in those equipped with sensitivity boosting RF devices (ion funnel, hexapole ion guide), the reduced electric field strength E/N can be precisely controlled and adjusted to the specific needs of the experiment. This is of utmost importance for dealing with "fragile" molecules like propylene glycol (PG) and vegetable glycerol (VG).
Extensive tests with different types of ENDS have shown that in addition to the established H3O+ also NO+ and, most importantly, NH4+ reagent ions, which are produced without the need of any toxic and corrosive ammonia with IONICON's exclusive method, are essential for investigating the full chemical picture. In all of our PTR-TOFMS instruments reagent ions can be rapidly switched between H3O+, NO+ and NH4+ with the SRI option.
Real-time exhaled breath analysis
Maximum hygiene and no memory effects with our dedicated breath sampling interface
Most existing online breath sampling interfaces for analytical instrumentation aim at buffering of exhaled breath samples in order to extend the time available for analysis. This is the exact opposite of what is required for exhaled breath analysis following ENDS use: split-second time resolved compound quantification during exhalation while getting rid of sticky compounds in the system as soon as the exhalation process has finished.
We at IONICON have developed a dedicated breath sampling interface, which can be directly connected to our PTR-TOFMS instruments for online quantification in real-time. Carefully selected materials in combination with a cold-spot free design prevent accumulation of undesirable signal background. Disposable mouth-pieces with an integrated "non-return valve" fulfill common hygiene standards and enable studies with a large number of participants in very short time periods.
High compound concentrations in the exhaled breath after a mouth-hold maneuver (no inhalation) do not cause saturation effects in the ultra-sensitive PTR-TOFMS instrument because of the integrated dilution solution, which is fully electronically controlled via the PTR-TOFMS control software.