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Atmospheric Pressure Interface Time-of-Flight (APi-TOF)

Based on the modular ioniTOF-MS platform and hexapole ion-guides

A Novel Atmospheric Pressure Interface Time-of-Flight (APi-TOF) Instrument for Simultaneous Detection of Positive and Negative Ions


The novel IONICON ioniAPi-TOF is a modular and flexible, compact and robust set-up consisting of one or two interconnected APi-TOFs used in parallel (for simultaneous positive and negative polarity) featuring the advanced IONICON hexapole ION-GUIDE technology. Our new APi-TOF platform is a very attractive instrument for gaining new insights in science, enabling:

  • simultaneous detection of positive and negative ions and
  • a broader detectable m/z range than established designs

The new IONICON APi-TOF solves two major issues of other current commercial APi-TOF setups:

  • only one polarity (positive or negative ion mode) is available and
  • the m/z range of the ions of interest need to be chosen carefully since other TOFs with quadrupole ion-guides can only be tuned on lower or higher m/z but not to cover the whole mass range.

Thus, particularly in atmospheric chemistry and environmental research important data will be inevitably lost if the ions do not match these parameters.

Overcome these obstacles and contact us for the ioniAPi-TOF!

The Hexapole ION-GUIDE advantage

The ioniAPi-TOF atmospheric pressure interface consists of a critical orifice for contact free sample introduction, two hexapole ION-GUIDEs for high ion transmission efficiency over a broad m/z range and a high performance pump for high sample throughput. This interface is coupled to an orthogonal TOF analyzer equipped with an ion mirror for increased mass resolution.

The advantage of the IONICON hexapole ION-GUIDE over conventional quadrupole interfaces is that the energy in the multipole is lower which decreases unwanted ion-chemistry artefacts. Another advantage is that the mass range that is transmitted through the multipole is much broader.

The ioniTOF advantage

The ioniAPi-TOF is optionally available as a system where both polarities of the TOF-MS, positive and negative, are enabled in parallel. Therefore, there is no need to switch or sacrifice valuable data. Two virtually identical versions of this setup with opposite polarity are integrated in one compact instrument so that ions with both polarities can be detected simultaneously. Alternatively the user can operate both systems independently and benefit from a very advantageous offer for the ioniAPi-TOF set-up.

Another advantage is that the ioniTOF is designed as a modular and flexible TOF-MS platform that allows you to choose the mass resolving power you need and also upgrade to higher resolution if you feel the need at a later stage of your experiments. 
Discover the ioniTOF ecosystem!

Recent publications

Dvorak, M., Schnegg, R., Salvenmoser, W. et al. Distinct pathways for zinc metabolism in the terrestrial slug Arion vulgaris. Sci Rep 9, 20089 (2019).

Brilke, S., Resch, J., Leiminger, M., Steiner, G., Tauber, C., Wlasits, P. J. & Winkler, P. M.: Precision characterization of three ultrafine condensation particle counters using singly charged salt clusters in the 1–4 nm size range generated by a bipolar electrospray source, Aerosol Science and Technology (2020),

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