FUSION PTR

Overview

• Ultra-clean FUSION reaction chamber for lowest LODs 
• New fast-SRI ion source design for nearly instant reagent ion switching and stable ionization conditions
• Clean reagent ion production 
• Certified TRU-E/N ion chemistry quality
• No RF-induced enhanced fragmentation
• Quantitative measurements down to ppqV levels
• No compound specific calibration needed
• Enhanced Volatility Range (EVR) option available
• Compatible to most IONICON accessories (CHARON particle inlet, Liquid Calibration Unit, Multiport Valve, etc.)

All of these benefits are commercially available with the FUSION PTR-TOF 10k instrument, achieving lowest limits of detection (< 1 pptV in 1 s) and extremely high sensitivities up to 80000 cps/ppbV at a TOF-MS mass resolution > 10000 m/dm.

fast-SRI FUSION Ion Source

fast-SRI improves the decoupling of the ion source from the reaction chamber providing lowest interferences with neutrals and parasitic reagent ions.

• Reagent ions include: H₃O⁺, NH₄⁺, NO⁺, O₂⁺
• Fast switching times between reagent ions (~1 s between quantitative proton transfer with H₃O⁺ and soft adduct ionisation with NH₄⁺)
• Ultra clean reagent ion purity (C₆H₆⁺/C₆H₇⁺ < 2% in H₃O⁺ mode)
• Patented ionic NH₄⁺ generation, no neutral ammonia needed (Patents: US9188564, EP2606505)

FUSION reaction chamber

A combination of an innovative RF-electrode design with a sophisticated pumping scheme, allows for unprecedented sensitivities and simultaneously keeps the reaction region extremely clean, resulting in market-leading limits of detection.

Ion-molecule reactions with organics occur in a fully-controlled environment of a novel ion-focusing RF reaction chamber operated at reduced pressures of 2-4 mbar. This guarantees the needed clean ion chemistry at predictable reaction energies (E/N) and reaction rate constants (k-rate) that are crucial for quantitative operation of PTR-MS.

• High sensitivities up to ~ 80000 cps/ppbV @ R = 10k (for selected compounds and settings)
• Unprecedented Limits of Detection < 1 pptV @ 1 s acquisition time
• Near instantaneous switching between high and low reaction energy (E/N)
• No significant transmission cutoff to high m/z  
• Also supports classic PTR DC mode

TRU-E/N

Providing a reliable and well-defined ion chemistry is one of the key priorities at IONICON. Naturally, this distinct feature also applies for FUSION PTR and is guaranteed by our patented TRU-E/N label.   

• TRU-E/N method (Patents: US10074531, EP3309817) allows to adjust reaction energies (E/N) in the presence of RF fields
• Branching ratios are very sensitive to the applied reaction energy (E/N)
• FUSION PTR reproduces the intensity ratios for all relevant pinonic acid product ions over a wide range of E/N
• No calibration is needed, calculation of concentrations based on k-rates is possible

FUSION PTR outperforms other state-of-the-art commercial CIMS instruments by far, combines highest sensitivities, lowest LoDs and high mass resolving power with the pure ion chemistry of a PTR-MS. Get your FUSION PTR now!

Technical Note in Analytical Chemistry

Ultrahigh Sensitivity PTR-MS Instrument with a Well-Defined Ion Chemistry
Tobias Reinecke, Markus Leiminger, Alfons Jordan, Armin Wisthaler, and Markus Müller
Analytical Chemistry Article ASAP
DOI: 10.1021/acs.analchem.3c02669