Our Projects in CEMIT
IONIMED actively conducted research within the KMT, Competence Center of Medicine in Tyrol, from 2004 to June 2009 (renamed CEMIT, Center of Excellence in Medicine and IT). Using PTR-MS, IONIMED performed two major clinical studies, where the breath of kidney failure patients undergoing kidney transplantation ("transplant study") and the breath of lung cancer ("lung cancer study") patients before and during therapy were analyzed.
For the real-time analysis of breath, PTR-MS systems were installed in two hospitals in Austria. The PTR-MS system is a highly sensitive and quantitative analytical instrument for determining the concentration of volatile organic compounds (VOCs) in the exhaled breath in real time. Due to its short response-time and high sensitivity a large number of volatiles can be analyzed without the need for sample preparation. Breath samples are analyzed while the patient exhales through the breath sampler.
Our goal was to identify potential biomarkers for certain diseases and to relate breath concentrations of certain volatile metabolites to their blood concentrations. Exact knowledge of these relationships for patients undergoing a medical procedure, e.g. dialysis, surgery or certain types of drug therapy, is needed to utilize the advantages of a non-invasive, real-time monitoring system such as our PTR-MS instrument.