In real-time breath analysis, the exhaled breath is directly analyzed without sample preparation. Recording complete breathing cycles, see the figure to the right,
yields the concentrations for the end-tidal (alveolar) fraction and also the inspired (room-air) concentrations, which can both be easily extracted by software. This provides immediate results and avoids complications often arising from sample collection and storage. Also, the measurement of unstable compounds that undergo rapid degradation may only be possible by real-time analysis.
As an example, using an IONICON PTR-TOF 6000 X2, several hundred compounds are measured simultaneously in real-time from a single exhalation with limits of detection in the ppt range (1 ppt = 0.001 ppb).
IONICON has actively participated in several medical research projects. Our customers can benefit from this expertise which allows us to develop optimized products and to consult our clients for their medical application and scientific study design. IONICON has developed a BET breath-sampling inlet for real-time breath analysis with IONICON PTR-MS systems, which utilizes disposable mouth-pieces, certified for clinical use.
Find out more about potential applications of real-time breath analysis with PTR-TOF, such as