The analytical procedure was as simple as effective: We analyzed the headspace above a synthacaine sample at two E/N ratios and with two reagent ions , respectively, and compared the product ion ratios with a NPS database. The result was a nearly perfect match for methiopropamine and benzocaine. Methiopropamine has been on the NPS market for quite some time now, is an analogue of methamphetamine (“crystal meth”) and thus possesses strong stimulant properties. Benzocaine on the other hand has no psychoactive effect, but is a local anesthetic that gives the user a sensation of numbness in the nose after insufflation, as it would be expected from real cocaine. Philipp Sulzer concludes:
“The NPS market is changing extremely fast because of changing legislation. This is a serious problem for NPS users as they are now even more frequently exposed to new unexplored, untested and dangerous chemicals. However, with IONICON’s PTR-MS instruments we can easily keep up as far as the analysis is concerned. The method is extremely fast, very selective and really simple to use.”
 M. Lanza et. al., J. Mass Spectrom, 48 (9) (2013), 1015-1018
 W.J. Acton et. al., Int. J. Mass Spectrom 360 (2014), 28-38
 M. Lanza, et al., J. Mass Spectrom.50 (2015) 427.
 Varying E/N (reduced electric field strength, i.e. the ratio of the electric field, E, to the buffer gas number density, N in the reaction drift tube), by simply changing the voltage applied across the drift tube, modifies the collisional energy between reagent ions and the neutral analytes. Fragmentation of the protonated molecular ions can be supported or suppressed by changing E/N and when the relative product ion yields are plotted against the applied E/N, characteristic “fingerprints” can result. Combining these E/N fingerprints with changing the ion-molecule chemistry by switching reagent ions (SRI-MS) provides information which enables the rapid identification of analyte molecules with a high level of confidence.