Implementing PTR-MS for Bioprocess Monitoring
PTR-MS offers new opportunities for monitoring of biotechnological processes. In research projects with academic and industrial partners, we have developed a PTR-MS solution for bioprocess monitoring.
Our Mission in Biotech Research
PTR-MS offers interesting opportunities for monitoring of biotechnological processes. The monitoring of volatile metabolites in the off-gas of bioprocesses, promises a direct access to highly relevant process information. The development of such an application to an industrial level involves the coordinated efforts in several areas.
Academic research on lab-scale fermenters, accompanied by biostatistics, and an in-depth understanding of the underlying metabolic processes is necessary to establish volatile marker compounds for bioprocess monitoring. The development of optimized analyzers, customized interfaces to the fermenter and a level of automation for industrial use, are challenges to be overcome by device developers, such as IONICON. The access to industrial-scale fermentations and input on the requirements, such as GMP (Good Manufacturing Practice) processes, necessitates a close collaboration with partners in the biopharmaceutical industry.