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FUSION PTR-TOFMS

FUSION PTR-TOFMS

FUSION PTR combines the novel Invion source with the revolutionary FUSION reaction chamber for ppqV limits of detection, highest sensitivities and TRU-E/N ion-chemistry quality.

Overview

  • Ultra-clean FUSION reaction chamber for lowest LODs 
  • New Invion source design for nearly instant reagent ion switching and stable ionization conditions
  • New optional bipolar TOF giving access to SRI- (CO3-) reagent ions
  • Clean reagent ion production 
  • Certified TRU-E/N ion chemistry quality
  • No RF-induced enhanced fragmentation
  • Quantitative measurements down to ppqV levels
  • No compound specific calibration needed
  • Enhanced Volatility Range (EVR) included
  • Compatible to most IONICON accessories (CHARON particle inlet, Liquid Calibration Unit, Multiport Valve, etc.)

All of these benefits are commercially available with the FUSION PTR-TOF 10 instrument, achieving lowest limits of detection (< 1 pptV in 1 s) and extremely high sensitivities up to 80000 cps/ppbV at a TOF-MS mass resolution > 10000 m/dm.

FUSION Invion Source

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Invion improves the decoupling of the ion source from the reaction chamber providing lowest interferences with neutrals and parasitic reagent ions.

  • Reagent ions include: H3O+, NH4+, NO+, O2+, with optional bipolar TOF: CO3-
  • Fast switching times between reagent ions (~1 s between quantitative proton transfer with H3O+ and soft adduct ionisation with NH4+)
  • Patented ionic NH4+ generation, no neutral ammonia needed (Patents: US11342171, CN111386590, EP3503161)

FUSION reaction chamber

fusion_sensitivities_0822.png

A combination of an innovative RF-electrode design with a sophisticated pumping scheme, allows for unprecedented sensitivities and simultaneously keeps the reaction region extremely clean, resulting in market-leading limits of detection.

Ion-molecule reactions with organics occur in a fully-controlled environment of a novel ion-focusing RF reaction chamber operated at reduced pressures of 2-4 mbar. This guarantees the needed clean ion chemistry at predictable reaction energies (E/N) and reaction rate constants (k-rate) that are crucial for quantitative operation of PTR-MS.

  • High sensitivities up to ~ 80000 cps/ppbV @ R = 10k (for selected compounds and settings)
  • Unprecedented Limits of Detection < 1 pptV @ 1 s acquisition time
  • Near instantaneous switching between high and low reaction energy (E/N)
  • No significant transmission cutoff to high m/z  
  • Also supports classic PTR DC mode

TRU-E/N

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Providing a reliable and well-defined ion chemistry is one of the key priorities at IONICON. Naturally, this distinct feature also applies for FUSION PTR and is guaranteed by our patented TRU-E/N label.

  • TRU-E/N method (Patents: US10074531, EP3309817) allows to adjust reaction energies (E/N) in the presence of RF fields
  • Branching ratios are very sensitive to the applied reaction energy (E/N)
  • FUSION PTR reproduces the intensity ratios for all relevant pinonic acid product ions over a wide range of E/N
  • No calibration is needed, calculation of concentrations based on k-rates is possible

 

The FUSION PTR-TOF Series outperforms other state-of-the-art commercial CIMS instruments by far, combines highest sensitivities, lowest LoDs and high mass resolving power with the pure ion chemistry of a PTR-MS. 

Technical Note in Analytical Chemistry

Ultrahigh Sensitivity PTR-MS Instrument with a Well-Defined Ion Chemistry
Tobias Reinecke, Markus Leiminger, Alfons Jordan, Armin Wisthaler, and Markus Müller
Analytical Chemistry Article ASAP
DOI: 10.1021/acs.analchem.3c02669

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