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Scientific Articles - PTR-MS Bibliography

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Found 4 results
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Filters: Author is Kassebacher, Thomas  [Clear All Filters]
[Kassebacher2013] Kassebacher, T., P. Sulzer, S. Juerschik, E. Hartungen, A. Jordan, A. Edtbauer, S. Feil, G. Hanel, S. Jaksch, L. Maerk, et al., "Investigations of chemical warfare agents and toxic industrial compounds with proton-transfer-reaction mass spectrometry for a real-time threat monitoring scenario.", Rapid Commun Mass Spectrom, vol. 27, no. 2: Austria., pp. 325–332, Jan, 2013.
Security and protection against terrorist attacks are major issues in modern society. One especially challenging task is the monitoring and protection of air conditioning and heating systems of buildings against terrorist attacks with toxic chemicals. As existing technologies have low selectivity, long response times or insufficient sensitivity, there is a need for a novel approach such as we present here.We have analyzed various chemical warfare agents (CWAs) and/or toxic industrial compounds (TICs) and related compounds, namely phosgene, diphosgene, chloroacetone, chloroacetophenone, diisopropylaminoethanol, and triethyl phosphate, utilizing a high-resolution proton-transfer-reaction time-of-flight mass spectrometry (PTR-TOFMS) instrument with the objective of finding key product ions and their intensities, which will allow a low-resolution quadrupole mass spectrometry based PTR-MS system to be used with high confidence in the assignment of threat agents in the atmosphere.We obtained high accuracy PTR-TOFMS mass spectra of the six compounds under study at two different values for the reduced electric field in the drift tube (E/N). From these data we have compiled a table containing product ions, and isotopic and E/N ratios for highly selective threat compound detection with a compact and cost-effective quadrupole-based PTR-MS instrument. Furthermore, using chloroacetophenone (tear gas), we demonstrated that this instrument's response is highly linear in the concentration range of typical Acute Exposure Guideline Levels (AEGLs).On the basis of the presented results it is possible to develop a compact and cost-effective PTR-QMS instrument that monitors air supply systems and triggers an alarm as soon as the presence of a threat agent is detected. We hope that this real-time surveillance device will help to seriously improve safety and security in environments vulnerable to terrorist attacks with toxic chemicals.
[Sulzer2012a] Sulzer, P., S. Juerschik, B. Agarwal, T. Kassebacher, E. Hartungen, A. Edtbauer, F. Petersson, J. Warmer, G. Holl, D. Perry, et al., "Designer Drugs and Trace Explosives Detection with the Help of Very Recent Advancements in Proton-Transfer-Reaction Mass Spectrometry (PTR-MS)", Future Security: Springer, pp. 366–375, 2012.
At the "Future Security 2011" we presented an overview of our studies on the "Detection and Identification of Illicit and Hazardous Substances with Proton-Transfer-Reaction Mass Spectrometry (PTR-MS)" including first results on explosives, chemical warfare agents and illicit and prescribed drugs detection. Since then we have considerably extended these preliminary studies to the detection of defined traces of some of the most common explosives, namely TNT, PETN, TATP, and DATP deposited into aluminum foam bodies, and to the detection of a number of novel and widely unknown designer drugs: ethylphenidate, 4-fluoroamphetamine and dimethocaine. Moreover, we have dramatically improved our time-of-flight based PTR-MS instruments by substantially increasing their sensitivity and hence lowering the detection limit, making them even more suitable and applicable to threat agents with extremely low vapour pressures. Data from measurements on certified gas standards are presented in order to underline these statements. The data demonstrate that, in comparison to the first generation instruments, a gain of one order of magnitude in terms of sensitivity and detection limit has been obtained.
[Kassebacher2012] Kassebacher, T., P. Sulzer, S. Juerschik, B. Agarwal, F. Petersson, E. Hartungen, H. Seehauser, and T. D. Maerk, "Detecting and Quantifying Toxic Industrial Compounds (TICs) with Proton-Transfer-Reaction Mass Spectrometry (PTR-MS)", Future Security: Springer, pp. 438–447, 2012.
In the course of the FP7-SEC project "SPIRIT" (Safety and Protection of built Infrastructure to Resist Integral Threats) we focused our research with Proton-Transfer-Reaction Mass Spectrometry (PTR-MS) on C-agents, specifically Toxic Industrial Compounds (TICs). Most TICs are readily available and represent a considerable threat when used in terroristic attacks. We show the principal procedure of PTR-MS detection measurements on two chemicals, namely phosgene and chloroacetone. With studies of the former we want to point out principle differences between measurements on a quadrupole mass filter based and a Time-of-Flight-based PTR-MS instrument and point out the respective benefits and drawbacks. For the latter we present the results of a diluted headspace measurement and illustrate the connection with security standards in buildings.
[Juerschik2012] Juerschik, S., B. Agarwal, T. Kassebacher, P. Sulzer, C. A. Mayhew, and T. D. Märk, "Rapid and facile detection of four date rape drugs in different beverages utilizing proton transfer reaction mass spectrometry (PTR-MS).", J Mass Spectrom, vol. 47, no. 9: IONICON Analytik GmbH., Eduard-Bodem-Gasse 3, 6020, Innsbruck, Austria., pp. 1092–1097, Sep, 2012.
In this work, we illustrate the application of proton transfer reaction mass spectrometry (PTR-MS) in the field of food and drink safety. We present proof-of-principle measurements of four different drinks (water, tea, red wine and white wine) each spiked separately with four different date rape drugs (chloral hydrate, tricholorethanol, γ-butyrolactone and butanediol). At first, the ideal PTR-MS operating conditions (reduced electric field strength and monitoring the most abundant [fragment] ion) for detection of the drugs were determined utilizing a time-of-flight-based PTR-MS instrument. We then dissolved small quantities of the drugs (below the activation threshold for effects on humans) into the various types of drinks and detected them using a quadrupole-based PTR-MS instrument via two different sampling methods: (1) dynamic headspace sampling and (2) direct liquid injection. Both methods have their advantages and drawbacks. Only with dynamic headspace sampling can rape drug contaminations be detected within a timeframe of seconds, and therefore, this method is the most promising use of PTR-MS as a fast, sensitive and selective monitor for the detection of food and drink contamination.

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Selected PTR-MS related Reviews

F. Biasioli, C. Yeretzian, F. Gasperi, T. D. Märk: PTR-MS monitoring of VOCs and BVOCs in food science and technology, Trends in Analytical Chemistry 30 (7) (2011).

J. de Gouw, C. Warneke, T. Karl, G. Eerdekens, C. van der Veen, R. Fall: Measurement of Volatile Organic Compounds in the Earth's Atmosphere using Proton-Transfer-Reaction Mass Spectrometry. Mass Spectrometry Reviews, 26 (2007), 223-257.

W. Lindinger, A. Hansel, A. Jordan: Proton-transfer-reaction mass spectrometry (PTR–MS): on-line monitoring of volatile organic compounds at pptv levels, Chem. Soc. Rev. 27 (1998), 347-375.


Lists with PTR-MS relevant publications of the University of Innsbruck can be found here: Atmospheric and indoor air chemistry, IMR, Environmental Physics and Nano-Bio-Physics


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