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Scientific Articles - PTR-MS Bibliography

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Found 5 results
Title [ Year(Asc)]
Filters: Author is Kohl, I.  [Clear All Filters]
[Kohl2012] Kohl, I.., J.. Dunkl, J.. Herbig, M.. Hubalek, H.. Fiegl, and M.. Daniaux, "Atemgasanalyse fuer eine zukuenftige nicht-invasive Medizin", GYNAEKOLOGISCHE ONKOLOGIE, vol. 6, pp. 21, 2012.
Die Zusammensetzung der Atemluft kann durch Erkrankungen verändert werden. Mit Hilfe von modernen analytischen Messmethoden versucht die Forschung, Zusammenhänge ­zwischen einzelnen Chemikalien und physiologischen bzw. pathologischen Vorgängen fest­zustellen. Ziel ist die nicht-invasive Frühdiagnostik von Krankheiten durch Atemgasanalysen. In einer Pilotstudie an der Innsbrucker Universitäts-Fraukenklinik wurden Atemgasproben von Brustkrebspatientinnen systematisch mit einer hochempfindlichen Methode analysiert. Eine ­signifikante ­Erniedrigung der Isopren-Konzentration der ausgeatmeten Luft vs. gesunde Kontrollen ist konsistent mit den ­Ergebnissen von Atemgasstudien bei Lungenkrebspatientinnen.
[Kohl2011a] Kohl, I.., J.. Dunkl, and A.. Hansel, "The average composition of exhaled breath of healthy women by PTR-TOF-MS", 5th International PTR-MS Conference on Proton Transfer Reaction Mass Spectrometry and Its Applications, pp. 34, 2011.
We analysed the exhaled breath of a cohort of 50 healthy women using Proton-Transfer-Reaction Time-of-Flight Mass Spectrometry (PTR-TOF-MS). To ensure that end-tidal exhaled air was collected, we used a Breath Collecting Unit, which sampled breath gas only when the CO2 signal was high. Samples were stored in inert Silco cans and analysed subsequently by PTR-TOF-MS. Components are characterized by their sum formula and were extracted from the raw data by matching them with a list of candidate compounds. A description of the average composition of the investigated cohort is given. These data can be helpful to identify compounds in breath measurements with quadrupole PTRMS systems, where a separation of isobaric compounds is not possible.
[Herbig2011] Herbig, J.., M.. Seger, I.. Kohl, K.. Winkler, H.. Jamnig, A.. Zabernigg, C.. Baumgartner, and A.. Hansel, "Breath Analysis with PTR-MS: More breath markers for lung cancer", 5th International PTR-MS Conference on Proton Transfer Reaction Mass Spectrometry and Its Applications, pp. 31-33, 2011.
In a clinical screening study we have measured several hundred subjects using real-time breath analysis with PTR-MS. We present and discuss potential breath markers for lung cancer with a critical view on the data analysis. The presented problems and solutions are also applicable to other analytical methods used in breath analysis.
[Mair2011] Mair, V.., J.. Dunkl, A.. Hansel, and I.. Kohl, "Breath gas analysis by PTR-TOF-MS in a clinical setting", 5th International PTR-MS Conference on Proton Transfer Reaction Mass Spectrometry and Its Applications, pp. 231, 2011.
Typical clinical (breath analysis) studies take several months to years. Employing a Proton-Transfer-Reaction Time-of-Flight Mass Spectrometer (PTR-TOF-MS) as an analytical tool for breath analysis, a constant performance of the instrument is essential. Here we report on the longterm performance of a PTR-TOF-MS for the analysis of exhaled breath gas in the frame of a clinical study. Performance data are shown for a period of 7 months. We characterized the sampling procedure, sample storage, and measured sensitivity and detection limit for a set of VOCs with relevance in breath analysis. Over the period of 7 months, we were able to achieve a high mass accuracy and precision in the range of ppm.
[Singer2007] Singer, W.., J.. Beauchamp, J.. Herbig, J.. Dunkl, I.. Kohl, and A.. Hansel, "Dynamic Gas Dilution System for Accurate Calibration of Analytical Instruments such as PTR-MS", 3rd International PTR-MS Conference on Proton Transfer Reaction Mass Spectrometry and Its Applications, pp. 232-237, 2007.

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Selected PTR-MS related Reviews

F. Biasioli, C. Yeretzian, F. Gasperi, T. D. Märk: PTR-MS monitoring of VOCs and BVOCs in food science and technology, Trends in Analytical Chemistry 30 (7) (2011).

J. de Gouw, C. Warneke, T. Karl, G. Eerdekens, C. van der Veen, R. Fall: Measurement of Volatile Organic Compounds in the Earth's Atmosphere using Proton-Transfer-Reaction Mass Spectrometry. Mass Spectrometry Reviews, 26 (2007), 223-257.

W. Lindinger, A. Hansel, A. Jordan: Proton-transfer-reaction mass spectrometry (PTR–MS): on-line monitoring of volatile organic compounds at pptv levels, Chem. Soc. Rev. 27 (1998), 347-375.


Lists with PTR-MS relevant publications of the University of Innsbruck can be found here: Atmospheric and indoor air chemistry, IMR, Environmental Physics and Nano-Bio-Physics


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