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Scientific Articles - PTR-MS Bibliography

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[Kohl2013a] Kohl, I., J. Beauchamp, F. Cakar-Beck, J. Herbig, J. Dunkl, O. Tietje, M. Tiefenthaler, C. Boesmueller, A. Wisthaler, M. Breitenlechner, et al., "Non-invasive detection of renal function via breath gas analysis: A potential biomarker for organ acceptance?", 6th International PTR-MS Conference on Proton Transfer Reaction Mass Spectrometry and Its Applications, pp. 24, 2013.
Breath gas analysis is an emerging field that attempts to link components in exhaled breath gas with state-of-health or illness [1]. This is based on the premise that disease in the body will elicit abnormal biochemical reactions which in turn produce chemical compounds that might be excreted by the body - at least in part - via exhalation. We used PTR-MS to directly sample and analyse selected VOC constituents in the exhaled breath of patients (n=96) undergoing kidney transplantation. Breath samples were taken before surgery and then over an extended period thereafter. Comparison of PTR-MS data with routine blood-serum data revealed a specific compound (ion trace) at m/z 115 that correlated with creatinine in blood serum and daily urine production, which are the current generally-accepted markers for kidney function. PTR-TOF analyses revealed that this compound had an exact molecular mass of 114.104 u and a chemical composition of C7H14O. Subsequent analyses using PTR-QqQ-MS suggested the compound to be a C7-ketone or branched C7-aldehyde. It is hoped that the results of this study will provide impetus to other researchers in the field to further delve into the nature of this compound and its possible biochemical production routes to ascertain the eligibility of this compound for potential use in future routine breath analysis for renal function assessment.

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Selected PTR-MS related Reviews

F. Biasioli, C. Yeretzian, F. Gasperi, T. D. Märk: PTR-MS monitoring of VOCs and BVOCs in food science and technology, Trends in Analytical Chemistry 30 (7) (2011).

J. de Gouw, C. Warneke, T. Karl, G. Eerdekens, C. van der Veen, R. Fall: Measurement of Volatile Organic Compounds in the Earth's Atmosphere using Proton-Transfer-Reaction Mass Spectrometry. Mass Spectrometry Reviews, 26 (2007), 223-257.

W. Lindinger, A. Hansel, A. Jordan: Proton-transfer-reaction mass spectrometry (PTR–MS): on-line monitoring of volatile organic compounds at pptv levels, Chem. Soc. Rev. 27 (1998), 347-375.


Lists with PTR-MS relevant publications of the University of Innsbruck can be found here: Atmospheric and indoor air chemistry, IMR, Environmental Physics and Nano-Bio-Physics


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