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Scientific Articles - PTR-MS Bibliography

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Publications

Found 3 results
Title [ Year(Asc)]
Filters: Author is Tietje, Olaf  [Clear All Filters]
2013
[Kohl2013b] Kohl, I., J. Beauchamp, F. Cakar-Beck, J. Herbig, J.. Dunkl, O. Tietje, M. Tiefenthaler, C. Boesmueller, A. Wisthaler, M. Breitenlechner, et al., "First observation of a potential non-invasive breath gas biomarker for kidney function.", J Breath Res, vol. 7, no. 1: Ionimed Analytik GmbH, Eduard Bodem Gasse 3, A-6020 Innsbruck, Austria., pp. 017110, Mar, 2013.
Link: http://dx.doi.org/10.1088/1752-7155/7/1/017110
Abstract
We report on the search for low molecular weight molecules-possibly accumulated in the bloodstream and body-in the exhaled breath of uremic patients with kidney malfunction. We performed non-invasive analysis of the breath gas of 96 patients shortly before and several times after kidney transplantation using proton-transfer-reaction mass spectrometry (PTR-MS), a very sensitive technique for detecting trace amounts of volatile organic compounds. A total of 642 individual breath analyses which included at least 41 different chemical components were carried out. Correlation analysis revealed one particular breath component with a molecular mass of 114 u (unified atomic mass units) that clearly correlated with blood serum creatinine, which is the currently accepted marker for assessing the function of the kidney. In particular, daily urine production showed good correlation with the identified breath marker. An independent set of seven samples taken from three patients at the onset of dialysis and three controls with normal kidney function confirmed a significant difference in concentration between patients and controls for a compound with a molecular mass of 114.1035 u using high mass resolving proton-transfer-reaction time-of-flight mass spectrometry (PTR-TOF-MS). A chemical composition of CHO was derived for the respective component. Fragmentation experiments on the same samples using proton-transfer-reaction triple-quadrupole tandem mass spectrometry (PTR-QqQ-MS) suggested that this breath marker is a C-ketone or a branched C-aldehyde. Non-invasive real-time monitoring of the kidney function via this breath marker could be a possible future procedure in the clinical setting.
2011
[Kohl2011] Kohl, I., J. Herbig, J. Beauchamp, J. Dunkl, O. Tietje, and A. Hansel, "Online breath analysis of volatile organic compounds with PTR-MS: a guanidino breath marker for the status of uremia and kidney transplant rejection diagnosis.", 4th International PTR-MS Conference on Proton Transfer Reaction Mass Spectrometry and Its Applications, pp. 251, 2011.
Link: http://www.ionicon.com/sites/default/files/uploads/doc/contributions_ptr_ms_Conference_5.pdf
2009
[Kohl2009] Kohl, I., J. Herbig, J. Beauchamp, J. Dunkl, O. Tietje, and A. Hansel, "Proton-transfer-reaction mass spectrometry online analysis of volatile organic compounds in the exhaled breath: kidney transplant rejection diagnosis", CONFERENCE SERIES, pp. 251, 2009.
Link: http://www.ionicon.com/sites/default/files/uploads/doc/contributions_ptr_ms_Conference_4.pdf#page=251

Featured Articles

Download Contributions to the International Conference on Proton Transfer Reaction Mass Spectrometry and Its Applications:

 

Selected PTR-MS related Reviews

F. Biasioli, C. Yeretzian, F. Gasperi, T. D. Märk: PTR-MS monitoring of VOCs and BVOCs in food science and technology, Trends in Analytical Chemistry 30 (7) (2011).
Link

J. de Gouw, C. Warneke, T. Karl, G. Eerdekens, C. van der Veen, R. Fall: Measurement of Volatile Organic Compounds in the Earth's Atmosphere using Proton-Transfer-Reaction Mass Spectrometry. Mass Spectrometry Reviews, 26 (2007), 223-257.
Link

W. Lindinger, A. Hansel, A. Jordan: Proton-transfer-reaction mass spectrometry (PTR–MS): on-line monitoring of volatile organic compounds at pptv levels, Chem. Soc. Rev. 27 (1998), 347-375.
Link

 

Lists with PTR-MS relevant publications of the University of Innsbruck can be found here: Atmospheric and indoor air chemistry, IMR, Environmental Physics and Nano-Bio-Physics

 

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