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Scientific Articles - PTR-MS Bibliography

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Found 24 results
Title [ Year(Asc)]
Filters: Author is Hansel, A.  [Clear All Filters]
2014
[1523] Herbig, J.., R.. Gutmann, K.. Winkler, A.. Hansel, and G.. Sprachmann, "Real-Time Monitoring of Trace Gas Concentrations in Syngas", Oil Gas Sci. Technol. Rev. IFP Energies nouvelles, vol. 69, pp. 363–372, August, 2014.
Link: http://ogst.ifpenergiesnouvelles.fr/articles/ogst/abs/2014/02/ogst120243/ogst120243.html
Abstract
<p>EN: A Proton Transfer Reaction Mass Spectrometer (PTR-MS) was used for the analysis of syngas in an industrial Fischer-Tropsch process. A PTR-MS can detect a variety of volatile organic and inorganic compounds in real-time and with high sensitivity. Together with a multiplexer, this allows for online (real-time) monitoring of the trace contaminations at different stages of a Fischer-Tropsch process. Several volatile compounds, such as HCN, H2S, RSH, carbonyls, acids, alcohols and others have been measured in Syngas. This paper describes the setup to monitor syngas using PTR-MS and summarizes the result of this proof-of-principle project. FR: Un spectromètre de masse par réaction de transfert de protons (PTR-MS, Proton Transfer Reaction &ndash; Mass Spectrometer) a été utilisé pour l&rsquo;analyse de gaz de synthèse dans un procédé industriel Fischer-Tropsch. Un PTR-MS peut détecter une grande variété de composés organiques et inorganiques volatils en temps réel et avec une sensibilité élevée. Associé à un multiplexeur, il permet un suivi en ligne (en temps réel) des contaminants à l&rsquo;état de traces à différents stades d&rsquo;un procédé Fischer-Tropsch. Plusieurs composés volatils, tels que HCN, H2S, RSH, des carbonyles, des acides, des alcools et autres, ont été mesurés dans du gaz de synthèse. Cet article décrit la configuration pour le suivi du gaz de synthèse en utilisant le PTR-MS et résume le résultat de ce projet de preuve de concept.</p>
2013
[Schmidberger2013] Schmidberger, T.., R.. Gutmann, and R.. Huber, "Application of PTR-MS in mammalian cell culture", 6th International PTR-MS Conference on Proton Transfer Reaction Mass Spectrometry and Its Applications, pp. 39, 2013.
Link: http://www.ionicon.com/sites/default/files/uploads/doc/contributions_ptr_ms_Conference_6.pdf
Abstract
Mass spectrometry is a well-known technology to detect O2 and CO2 in the off-gas of cell culture fermentations. In contrast to classical spectrometers, the proton transfer reaction mass spectrometer (PTR-MS) applies a very soft ionization strategy and therefore the spectra show less fragments and are easier to interpret. In our study we applied the PTR-MS technology to monitor volatile organic compounds (VOC) in mammalian cell culture processes. Interesting masses were identified and correlations between PTR-MS data and off-line parameters will be presented.
[Fischer2013a] Fischer, L., A. Klinger, J. Herbig, K. Winkler, R. Gutmann, and A. Hansel, "The LCU: Versatile Trace Gas Calibration", 6th International PTR-MS Conference on Proton Transfer Reaction Mass Spectrometry and Its Applications, pp. 192, 2013.
Link: http://www.ionicon.com/sites/default/files/uploads/doc/contributions_ptr_ms_Conference_6.pdf
[Fischer2013] Fischer, L., V. Ruzsanyi, K. Winkler, R. Gutmann, A. Hansel, and J. Herbig, "Micro-Capillary-Column PTR-TOF", 6th International PTR-MS Conference on Proton Transfer Reaction Mass Spectrometry and Its Applications, pp. 162, 2013.
Link: http://www.ionicon.com/sites/default/files/uploads/doc/contributions_ptr_ms_Conference_6.pdf
[Kohl2013a] Kohl, I., J. Beauchamp, F. Cakar-Beck, J. Herbig, J. Dunkl, O. Tietje, M. Tiefenthaler, C. Boesmueller, A. Wisthaler, M. Breitenlechner, et al., "Non-invasive detection of renal function via breath gas analysis: A potential biomarker for organ acceptance?", 6th International PTR-MS Conference on Proton Transfer Reaction Mass Spectrometry and Its Applications, pp. 24, 2013.
Link: http://www.ionicon.com/sites/default/files/uploads/doc/contributions_ptr_ms_Conference_6.pdf
Abstract
Breath gas analysis is an emerging field that attempts to link components in exhaled breath gas with state-of-health or illness [1]. This is based on the premise that disease in the body will elicit abnormal biochemical reactions which in turn produce chemical compounds that might be excreted by the body - at least in part - via exhalation. We used PTR-MS to directly sample and analyse selected VOC constituents in the exhaled breath of patients (n=96) undergoing kidney transplantation. Breath samples were taken before surgery and then over an extended period thereafter. Comparison of PTR-MS data with routine blood-serum data revealed a specific compound (ion trace) at m/z 115 that correlated with creatinine in blood serum and daily urine production, which are the current generally-accepted markers for kidney function. PTR-TOF analyses revealed that this compound had an exact molecular mass of 114.104 u and a chemical composition of C7H14O. Subsequent analyses using PTR-QqQ-MS suggested the compound to be a C7-ketone or branched C7-aldehyde. It is hoped that the results of this study will provide impetus to other researchers in the field to further delve into the nature of this compound and its possible biochemical production routes to ascertain the eligibility of this compound for potential use in future routine breath analysis for renal function assessment.
[Gutmann2013] Gutmann, R., M. Luchner, J. Herbig, F. Strobl, H. Armin, K. Bayer, and G. Striedner, "Realtime measurement of volatile components in the bioreactor via proton transfer reaction mass spectrometry (PTR-MS)–an approach for advanced bioprocess monitoring", 6th International PTR-MS Conference on Proton Transfer Reaction Mass Spectrometry and Its Applications, pp. 32, 2013.
Link: http://www.uibk.ac.at/iup/buch_pdfs/ptrms_2013.pdf#page=33
2012
[Gutmann2012] Gutmann, R.., M.. Luchner, J.. Herbig, A.. Hansel, K.. Bayer, and G.. Striedner, "Advanced bioprocess monitoring by implementation of Proton Transfer Reaction - Mass Spectrometry (PTR-MS) for measurement of volatile components in the bioreactor", ACIB, Book of abstracts, vol. -, pp. -, 2012.
2011
[Kohl2011a] Kohl, I.., J.. Dunkl, and A.. Hansel, "The average composition of exhaled breath of healthy women by PTR-TOF-MS", 5th International PTR-MS Conference on Proton Transfer Reaction Mass Spectrometry and Its Applications, pp. 34, 2011.
Link: http://www.ionicon.com/sites/default/files/uploads/doc/contributions_ptr_ms_Conference_5.pdf
Abstract
We analysed the exhaled breath of a cohort of 50 healthy women using Proton-Transfer-Reaction Time-of-Flight Mass Spectrometry (PTR-TOF-MS). To ensure that end-tidal exhaled air was collected, we used a Breath Collecting Unit, which sampled breath gas only when the CO2 signal was high. Samples were stored in inert Silco cans and analysed subsequently by PTR-TOF-MS. Components are characterized by their sum formula and were extracted from the raw data by matching them with a list of candidate compounds. A description of the average composition of the investigated cohort is given. These data can be helpful to identify compounds in breath measurements with quadrupole PTRMS systems, where a separation of isobaric compounds is not possible.
[Kohl2011a] Kohl, I.., J.. Dunkl, and A.. Hansel, "The average composition of exhaled breath of healthy women by PTR-TOF-MS", 5th International PTR-MS Conference on Proton Transfer Reaction Mass Spectrometry and Its Applications, pp. 34, 2011.
Link: http://www.ionicon.com/sites/default/files/uploads/doc/contributions_ptr_ms_Conference_5.pdf
Abstract
We analysed the exhaled breath of a cohort of 50 healthy women using Proton-Transfer-Reaction Time-of-Flight Mass Spectrometry (PTR-TOF-MS). To ensure that end-tidal exhaled air was collected, we used a Breath Collecting Unit, which sampled breath gas only when the CO2 signal was high. Samples were stored in inert Silco cans and analysed subsequently by PTR-TOF-MS. Components are characterized by their sum formula and were extracted from the raw data by matching them with a list of candidate compounds. A description of the average composition of the investigated cohort is given. These data can be helpful to identify compounds in breath measurements with quadrupole PTRMS systems, where a separation of isobaric compounds is not possible.
[Herbig2011] Herbig, J.., M.. Seger, I.. Kohl, K.. Winkler, H.. Jamnig, A.. Zabernigg, C.. Baumgartner, and A.. Hansel, "Breath Analysis with PTR-MS: More breath markers for lung cancer", 5th International PTR-MS Conference on Proton Transfer Reaction Mass Spectrometry and Its Applications, pp. 31-33, 2011.
Link: http://www.ionicon.com/sites/default/files/uploads/doc/contributions_ptr_ms_Conference_5.pdf
Abstract
In a clinical screening study we have measured several hundred subjects using real-time breath analysis with PTR-MS. We present and discuss potential breath markers for lung cancer with a critical view on the data analysis. The presented problems and solutions are also applicable to other analytical methods used in breath analysis.
[Herbig2011] Herbig, J.., M.. Seger, I.. Kohl, K.. Winkler, H.. Jamnig, A.. Zabernigg, C.. Baumgartner, and A.. Hansel, "Breath Analysis with PTR-MS: More breath markers for lung cancer", 5th International PTR-MS Conference on Proton Transfer Reaction Mass Spectrometry and Its Applications, pp. 31-33, 2011.
Link: http://www.ionicon.com/sites/default/files/uploads/doc/contributions_ptr_ms_Conference_5.pdf
Abstract
In a clinical screening study we have measured several hundred subjects using real-time breath analysis with PTR-MS. We present and discuss potential breath markers for lung cancer with a critical view on the data analysis. The presented problems and solutions are also applicable to other analytical methods used in breath analysis.
[Mair2011] Mair, V.., J.. Dunkl, A.. Hansel, and I.. Kohl, "Breath gas analysis by PTR-TOF-MS in a clinical setting", 5th International PTR-MS Conference on Proton Transfer Reaction Mass Spectrometry and Its Applications, pp. 231, 2011.
Link: http://www.ionicon.com/sites/default/files/uploads/doc/contributions_ptr_ms_Conference_5.pdf
Abstract
Typical clinical (breath analysis) studies take several months to years. Employing a Proton-Transfer-Reaction Time-of-Flight Mass Spectrometer (PTR-TOF-MS) as an analytical tool for breath analysis, a constant performance of the instrument is essential. Here we report on the longterm performance of a PTR-TOF-MS for the analysis of exhaled breath gas in the frame of a clinical study. Performance data are shown for a period of 7 months. We characterized the sampling procedure, sample storage, and measured sensitivity and detection limit for a set of VOCs with relevance in breath analysis. Over the period of 7 months, we were able to achieve a high mass accuracy and precision in the range of ppm.
[Mair2011] Mair, V.., J.. Dunkl, A.. Hansel, and I.. Kohl, "Breath gas analysis by PTR-TOF-MS in a clinical setting", 5th International PTR-MS Conference on Proton Transfer Reaction Mass Spectrometry and Its Applications, pp. 231, 2011.
Link: http://www.ionicon.com/sites/default/files/uploads/doc/contributions_ptr_ms_Conference_5.pdf
Abstract
Typical clinical (breath analysis) studies take several months to years. Employing a Proton-Transfer-Reaction Time-of-Flight Mass Spectrometer (PTR-TOF-MS) as an analytical tool for breath analysis, a constant performance of the instrument is essential. Here we report on the longterm performance of a PTR-TOF-MS for the analysis of exhaled breath gas in the frame of a clinical study. Performance data are shown for a period of 7 months. We characterized the sampling procedure, sample storage, and measured sensitivity and detection limit for a set of VOCs with relevance in breath analysis. Over the period of 7 months, we were able to achieve a high mass accuracy and precision in the range of ppm.
[Fischer2011] Fischer, L.., K.. Winkler, R.. Gutmann, W.. Singer, J.. Herbig, and A.. Hansel, "Evaporating Liquid Samples for Analysis with PTR-MS", 5th International PTR-MS Conference on Proton Transfer Reaction Mass Spectrometry and Its Applications, pp. 211–212, 2011.
Link: http://www.ionicon.com/sites/default/files/uploads/doc/contributions_ptr_ms_Conference_5.pdf
Abstract
We present a method for measuring liquid samples with the PTR-MS by using a spray to convert the liquid into the gas phase. Advantages over headspace measurements concerning compounds with high Henry's law constants could be demonstrated.
[Fischer2011] Fischer, L.., K.. Winkler, R.. Gutmann, W.. Singer, J.. Herbig, and A.. Hansel, "Evaporating Liquid Samples for Analysis with PTR-MS", 5th International PTR-MS Conference on Proton Transfer Reaction Mass Spectrometry and Its Applications, pp. 211–212, 2011.
Link: http://www.ionicon.com/sites/default/files/uploads/doc/contributions_ptr_ms_Conference_5.pdf
Abstract
We present a method for measuring liquid samples with the PTR-MS by using a spray to convert the liquid into the gas phase. Advantages over headspace measurements concerning compounds with high Henry's law constants could be demonstrated.
[Striedner2011] Striedner, G.., M.. Luchner, R.. Gutmann, A.. Hansel, and K.. Bayer, "Implementation of PTR-MS as tool in bioprocess monitoring - measurement of volatile components in the bioreactor exhaust gas", 5th International PTR-MS Conference on Proton Transfer Reaction Mass Spectrometry and Its Applications, pp. 24, 2011.
Link: http://www.ionicon.com/sites/default/files/uploads/doc/contributions_ptr_ms_Conference_5.pdf
Abstract
Common bioprocess conditions imply a gas-liquid-mixture with living cells as solid phase in a sterile environment which demands a great deal on sensor/analyzer technology and design. Online access to physiology relevant process variables, the ultimate request of process engineers, is still very limited as complexity of biological systems additionally constrains direct measurements...
[Striedner2011] Striedner, G.., M.. Luchner, R.. Gutmann, A.. Hansel, and K.. Bayer, "Implementation of PTR-MS as tool in bioprocess monitoring - measurement of volatile components in the bioreactor exhaust gas", 5th International PTR-MS Conference on Proton Transfer Reaction Mass Spectrometry and Its Applications, pp. 24, 2011.
Link: http://www.ionicon.com/sites/default/files/uploads/doc/contributions_ptr_ms_Conference_5.pdf
Abstract
Common bioprocess conditions imply a gas-liquid-mixture with living cells as solid phase in a sterile environment which demands a great deal on sensor/analyzer technology and design. Online access to physiology relevant process variables, the ultimate request of process engineers, is still very limited as complexity of biological systems additionally constrains direct measurements...
[Kohl2011] Kohl, I., J. Herbig, J. Beauchamp, J. Dunkl, O. Tietje, and A. Hansel, "Online breath analysis of volatile organic compounds with PTR-MS: a guanidino breath marker for the status of uremia and kidney transplant rejection diagnosis.", 4th International PTR-MS Conference on Proton Transfer Reaction Mass Spectrometry and Its Applications, pp. 251, 2011.
Link: http://www.ionicon.com/sites/default/files/uploads/doc/contributions_ptr_ms_Conference_5.pdf
2010
[1585] Bamberger, I.., L.. Hortnagl, R.. Schnitzhofer, M.. Graus, T.. M. Ruuskanen, M.. Muller, J.. Dunkl, G.. Wohlfahrt, and A.. Hansel, "BVOC fluxes above mountain grassland.", Biogeosciences, vol. 7, May, 2010.
Link: http://www.biogeosciences.net/7/1413/2010/bg-7-1413-2010.html
Abstract
<p>Grasslands comprise natural tropical savannah over managed temperate fields to tundra and cover one quarter of the Earth&#39;s land surface. Plant growth, maintenance and decay result in volatile organic compound (VOCs) emissions to the atmosphere. Furthermore, biogenic VOCs (BVOCs) are emitted as a consequence of various environmental stresses including cutting and drying during harvesting. Fluxes of BVOCs were measured with a proton-transfer-reaction-mass-spectrometer (PTR-MS) over temperate mountain grassland in Stubai Valley (Tyrol, Austria) over one growing season (2008). VOC fluxes were calculated from the disjunct PTR-MS data using the virtual disjunct eddy covariance method and the gap filling method. Methanol fluxes obtained with the two independent flux calculation methods were highly correlated (y = 0.95&times;-0.12, R (2) = 0.92). Methanol showed strong daytime emissions throughout the growing season - with maximal values of 9.7 nmol m(-2) s(-1), methanol fluxes from the growing grassland were considerably higher at the beginning of the growing season in June compared to those measured during October (2.5 nmol m(-2) s(-1)). Methanol was the only component that exhibited consistent fluxes during the entire growing periods of the grass. The cutting and drying of the grass increased the emissions of methanol to up to 78.4 nmol m(-2) s(-1). In addition, emissions of acetaldehyde (up to 11.0 nmol m(-2) s(-1)), and hexenal (leaf aldehyde, up to 8.6 nmol m(-2) s(-1)) were detected during/after harvesting.</p>
[Singer2010] Singer, W.., R.. Gutmann, J.. Dunkl, and A.. Hansel, "PTR-MS Technology for Process Monitoring and Control in Biotechnology", Process Analytical Chemistry, vol. -, pp. -, 2010.
Link: http://www.infoscience.com/JPAC/ManScDB/JPACDBEntries/1265910397.pdf
2009
[Herbig2009] Herbig, J., M. Seger, I. Kohl, G. Mayramhof, T. Titzmann, A. Preinfalk, K. Winkler, J. Dunkl, B. Pfeifer, C. Baumgartner, et al., "Online breath sampling with PTR-MS - A setup for large screening studies", 4th International PTR-MS Conference on Proton Transfer Reaction Mass Spectrometry and Its Applications, pp. 46, 2009.
Link: http://www.ionicon.com/sites/default/files/uploads/doc/contributions_ptr_ms_Conference_4.pdf
2007
[Singer2007] Singer, W.., J.. Beauchamp, J.. Herbig, J.. Dunkl, I.. Kohl, and A.. Hansel, "Dynamic Gas Dilution System for Accurate Calibration of Analytical Instruments such as PTR-MS", 3rd International PTR-MS Conference on Proton Transfer Reaction Mass Spectrometry and Its Applications, pp. 232-237, 2007.
Link: http://www.ionicon.com/sites/default/files/uploads/doc/contributions_ptr_ms_Conference_3.pdf
[Singer2007] Singer, W.., J.. Beauchamp, J.. Herbig, J.. Dunkl, I.. Kohl, and A.. Hansel, "Dynamic Gas Dilution System for Accurate Calibration of Analytical Instruments such as PTR-MS", 3rd International PTR-MS Conference on Proton Transfer Reaction Mass Spectrometry and Its Applications, pp. 232-237, 2007.
Link: http://www.ionicon.com/sites/default/files/uploads/doc/contributions_ptr_ms_Conference_3.pdf
1997
[Taucher1997] Taucher, J.., A.. Hansel, A.. Jordan, R.. Fall, J.. H. Futrell, and W.. Lindinger, "Detection of isoprene in expired air from human subjects using proton-transfer-reaction mass spectrometry.", Rapid Commun. Mass Spectrom., vol. 11, pp. 1230-4, 1997.
Link: http://www.ncbi.nlm.nih.gov/pubmed/9260307
Abstract
A new analytical method using proton-transfer-reaction mass spectrometry (PTRMS) is described for the determination of trace constituents in human breath. PTRMS is sufficiently sensitive and specific that it does not require preconcentration or separation. At its present stage of development it is capable of detecting trace constituents present in air at the part-per-billion level. These capabilities are illustrated for isoprene, one of the most abundant endogenous hydrocarbons. Our results confirm recent observations of a diurnal level variation associated with sleep or wakefulness; a new finding is that young children have much lower levels of isoprene in breath than adults. To address the metabolic origin of human isoprene, we used PTRMS to analyze expired air for allylic C5 alcohols that have been proposed to be non-enzymatic precursors of isoprene. The lack of correlation between peak breath isoprene and these alcohols suggests that the hydrocarbon is formed by some other mechanism.

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Selected PTR-MS related Reviews

F. Biasioli, C. Yeretzian, F. Gasperi, T. D. Märk: PTR-MS monitoring of VOCs and BVOCs in food science and technology, Trends in Analytical Chemistry 30 (7) (2011).
Link

J. de Gouw, C. Warneke, T. Karl, G. Eerdekens, C. van der Veen, R. Fall: Measurement of Volatile Organic Compounds in the Earth's Atmosphere using Proton-Transfer-Reaction Mass Spectrometry. Mass Spectrometry Reviews, 26 (2007), 223-257.
Link

W. Lindinger, A. Hansel, A. Jordan: Proton-transfer-reaction mass spectrometry (PTR–MS): on-line monitoring of volatile organic compounds at pptv levels, Chem. Soc. Rev. 27 (1998), 347-375.
Link

 

Lists with PTR-MS relevant publications of the University of Innsbruck can be found here: Atmospheric and indoor air chemistry, IMR, Environmental Physics and Nano-Bio-Physics

 

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