Callback Service

Undefined

The world's leading PTR-MS company

Providing ultra-sensitive solutions for real-time trace gas analysis since 1998

Navigation

You are here

Scientific Articles - PTR-MS Bibliography

Welcome to the new IONICON scientific articles database!

Publications

Found 767 results
Title [ Year(Asc)]
2013
[Kohl2013a] Kohl, I., J. Beauchamp, F. Cakar-Beck, J. Herbig, J. Dunkl, O. Tietje, M. Tiefenthaler, C. Boesmueller, A. Wisthaler, M. Breitenlechner, et al., "Non-invasive detection of renal function via breath gas analysis: A potential biomarker for organ acceptance?", 6th International PTR-MS Conference on Proton Transfer Reaction Mass Spectrometry and Its Applications, pp. 24, 2013.
Link: http://www.ionicon.com/sites/default/files/uploads/doc/contributions_ptr_ms_Conference_6.pdf
Abstract
Breath gas analysis is an emerging field that attempts to link components in exhaled breath gas with state-of-health or illness [1]. This is based on the premise that disease in the body will elicit abnormal biochemical reactions which in turn produce chemical compounds that might be excreted by the body - at least in part - via exhalation. We used PTR-MS to directly sample and analyse selected VOC constituents in the exhaled breath of patients (n=96) undergoing kidney transplantation. Breath samples were taken before surgery and then over an extended period thereafter. Comparison of PTR-MS data with routine blood-serum data revealed a specific compound (ion trace) at m/z 115 that correlated with creatinine in blood serum and daily urine production, which are the current generally-accepted markers for kidney function. PTR-TOF analyses revealed that this compound had an exact molecular mass of 114.104 u and a chemical composition of C7H14O. Subsequent analyses using PTR-QqQ-MS suggested the compound to be a C7-ketone or branched C7-aldehyde. It is hoped that the results of this study will provide impetus to other researchers in the field to further delve into the nature of this compound and its possible biochemical production routes to ascertain the eligibility of this compound for potential use in future routine breath analysis for renal function assessment.
[Fares2013] Fares, S., R. Schnitzhofer, X. Jiang, A. Guenther, A. Hansel, and F. Loreto, "Observations of diurnal to weekly variations of monoterpene-dominated fluxes of volatile organic compounds from Mediterranean forests: implications for regional modeling.", Environ Sci Technol, Sep, 2013.
Link: http://dx.doi.org/10.1021/es4022156
Abstract
The Estate of Castelporziano (Rome, Italy) hosts many ecosystems representative of Mediterranean vegetation, especially holm oak and pine forests, and dune vegetation. In this work, Basal Emission Factors (BEFs) of biogenic volatile organic compounds (BVOCs) obtained by Eddy Covariance in a field campaign using a Proton Transfer Reaction - Time of Flight - Mass Spectrometer (PTR-TOF-MS) were compared to BEFs reported in previous studies that could not measure fluxes in real-time. Globally, broadleaf forests are dominated by isoprene emissions, but these Mediterranean ecosystems are dominated by strong monoterpene emitters, as shown by the new BEFs. The original and new BEFs were used to parameterize the Model of Emissions of Gases and Aerosols from Nature (MEGAN v2.1), and model outputs were compared with measured fluxes. Results showed good agreement between modelled and measured fluxes when a model was used to predict radiative transfer and energy balance across the canopy. We then evaluated whether changes in BVOC emissions can affect the chemistry of the atmosphere and climate at a regional level. MEGAN was run together with the land surface model (Community Land Model, CLM v4.0) of the Community Earth System Model (CESM v1.0). Results highlighted that tropospheric ozone concentration and air temperature predicted from the model are sensitive to the magnitude of BVOC emissions, thus demonstrating the importance of adopting the proper BEF values for model parameterization.
[Gloess2013a] Gloess, A. N., A. Vietri, S. Bongers, T. Koziorowski, and C. Yeretzian, "On-line Analysis of the Coffee Roasting Process with PTR-ToF-MS: Evidence of Different Flavor Formation Dynamics for Different Coffee Varieties", CONFERENCE SERIES, pp. 166, 2013.
Link: http://www.ionicon.com/sites/default/files/uploads/doc/contributions_ptr_ms_Conference_6.pdf
[1667] Inomata, S., H. Tanimoto, Y. Fujitani, K. Sekimoto, K. Sato, A. Fushimi, H. Yamada, S. Hori, Y. Kumazawa, A. Shimono, et al., "On-line measurements of gaseous nitro-organic compounds in diesel vehicle exhaust by proton-transfer-reaction mass spectrometry", Atmospheric Environment, vol. 73, pp. 195–203, Jul, 2013.
Link: http://dx.doi.org/10.1016/j.atmosenv.2013.03.035
Abstract
<p>Nitro-organic compounds, some of which cause adverse health effects in humans, are emitted in diesel engine exhaust. Speciation and quantification of these nitro-organic compounds in diesel engine exhaust particles have been extensively conducted; however, investigations into the emissions of gaseous nitro-organic compounds in diesel engine exhaust have not. In the present study, the properties of gaseous nitro-organic compounds in diesel engine exhaust were investigated through time-resolved measurement with a proton-transfer-reaction mass spectrometer and a chassis dynamometer. Three diesel trucks were tested, each with a different type of exhaust-gas treatment system (i.e., aftertreatment). Among the nitro-organic compounds detected, the emission of nitromethane was commonly observed and found to be related to the emissions of carbon monoxide, benzene, and acetone. The emission of other nitro-organic compounds, such as nitrophenol, depended on the vehicle, possibly due to the type of aftertreatment installed.</p>
[1456] Zardin, E., O. Tyapkova, A. Buettner, and J. Beauchamp, "Performance assessment of proton-transfer-reaction time-of-flight mass spectrometry (PTR-TOF-MS) for analysis of isobaric compounds in food-flavour applications", \{LWT\} - Food Science and Technology, pp. -, 2013.
Link: http://www.sciencedirect.com/science/article/pii/S0023643813003964
Abstract
<p>Abstract Characterisation of food-flavour release using quadrupole-based on-line mass spectrometers such as proton-transfer-reaction mass spectrometry (PTR-MS, or PTR-QMS) can be complicated when nominally isobaric aroma compounds are present in complex food matrices. The recent combination of PTR-MS with time-of-flight mass spectrometry (PTR-TOF-MS) offers an analytical tool potentially capable of overcoming this problem because of its enhanced mass resolution. In this context, four pairs of isobaric compounds (cis-3-hexenol and 2,3-pentanedione, benzaldehyde and m-xylene, ethyl butanoate and 2-methylbutanol, and isobutyl isopentanoate and 1-hexanol) were investigated by PTR-TOF-MS to assess its mass-resolving power for food-flavour applications. Headspace analyses of aqueous solutions containing nominally isobaric aroma compounds that are unresolvable by PTR-QMS demonstrated that the PTR-TOF-MS mass-resolving power, which is m/z-dependent, enabled discrimination between isobaric peaks at a centre of mass separation down to at least 0.030&nbsp;Da. Visual discrimination between these isobaric compound peaks in the headspace of aqueous solutions down to a concentration range of a few tens of ng&nbsp;mL&minus;1 was also possible, enabling an empirical method for determining the limit of quantitation in solution for single compounds. PTR-TOF-MS offers distinct advantages over conventional PTR-MS for certain flavour release applications.</p>
[Sidheswaran2013] Sidheswaran, M., S. Cohn, D. P. Sullivan, and L. A. Gundel, "Performance Evaluation of Real Time Formaldehyde Monitors: PTR-MS and Interscan 4160-500B Portable Monitor", , 2013.
Link: http://eetd.lbl.gov/sites/all/files/lbnl-6357e.pdf
[1458] Beauchamp, J., J. Herbig, J. Dunkl, W. Singer, and A. Hansel, "On the performance of proton-transfer-reaction mass spectrometry for breath-relevant gas matrices", Measurement Science and Technology, vol. 24, pp. 125003, 2013.
Link: http://stacks.iop.org/0957-0233/24/i=12/a=125003
[Gloess2013] Gloess, A. N., M. Wellinger, B. Schoenbaechler, F. Wieland, C. Lindinger, and C. Yeretzian, "Predicting the Sensory Profiles of Coffee based on PTR-ToF-MS and GC-MS Measurements", CONFERENCE SERIES, pp. 54, 2013.
Link: http://www.ionicon.com/sites/default/files/uploads/doc/contributions_ptr_ms_Conference_6.pdf
[Yanagisawa2013] Yanagisawa, N., and K. Enya, "Preliminary results of measurement of volatile compounds adsorbed on diesel exhaust particles by PTR-TOFMS", CONFERENCE SERIES, pp. 239, 2013.
Link: http://www.ionicon.com/sites/default/files/uploads/doc/contributions_ptr_ms_Conference_6.pdf
[1594] Schuhfried, E., T. D. Märk, and F. Biasioli, "Primary Ion Depletion Kinetics (PIDK) Studies as a New Tool for Investigating Chemical Ionization Fragmentation Reactions with PTR-MS.", PLoS One, vol. 8, pp. e66925, 2013.
Link: http://dx.doi.org/10.1371/journal.pone.0066925
Abstract
<p>We report on a new approach for studying fragmentation channels in Proton Transfer Reaction-Mass Spectrometry (PTR-MS), which we name primary ion depletion kinetics (PIDK). PTR-MS is a chemical ionization mass spectrometric (CIMS) technique deploying hydronium ions for the chemical ionization. Induced by extremely high concentrations of analyte M, depletion of the primary ions in the drift tube occurs. This is observed as quasi zero concentration of the primary ion H3O(+), and constant MH(+). Under these non-standard conditions, we find an overall changed fragmentation. We offer two explanations. Either the changed fragmentation pattern is the result of secondary proton transfer reactions. Or, alternatively, the fast depletion of H3O(+) leads to reduced heating of H3O(+) in the drift field, and consequently changed fragmentation following protonation of the analyte M. In any case, we use the observed changes in fragmentation as a successful new approach to fragmentation studies, and term it primary ion depletion kinetics, PIDK. PIDK easily yields an abundance of continuous data points with little deviation, because they are obtained in one experimental run, even for low abundant fragments. This is an advantage over traditional internal kinetic energy variation studies (electric field per number density (E/N) variation studies). Also, some interpretation on the underlying fragmentation reaction mechanisms can be gleamed. We measure low occurring fragmentation (&lt;2% of MH(+)) of the compounds dimethyl sulfide, DMS, a compound that reportedly does not fragment, diethyl sulfide DES, and dipropyl sulfide DPS. And we confirm and complement the results with traditional E/N studies. Summing up, the new approach of primary ion depletion kinetics allows for the identification of dehydrogenation [MH(+) -H2] and adduct formation (RMH(+)) as low abundant fragmentation channels in monosulfides.</p>
[Zhang2013] Zhang, G., S. Nan Gao, W. Ding Wei, and Q. Jian Xu, "Proton Transfer Reaction-Mass Spectrometry Determination of the Emission Rate of Flavor Ingredients in Toothpastes", Applied Mechanics and Materials, vol. 299: Trans Tech Publ, pp. 229–232, 2013.
Link: http://www.scientific.net/AMM.299.229
Abstract
Under the experimental conditions, the headspace concentration of two flavor ingredients in toothpastes, limonene (C10H16) and menthone (C10H18O), was measured with proton transfer reaction - mass spectrometry (PTR-MS). Combined with the theoretical diffusion model and analytical solution, the partition coefficient and the emission rate of the two ingredients from toothpaste diluent to the circulated air were calculated. Theoretical Solutions of the distribution coefficients were obtained respectively as 0.00432 and 0.00418 for C10H16 and C10H18O. The corresponding simulated flavor concentration in headspace air Ca(t) had good agreement with the experimental values (R2 = 0.983 and 0.958 respectively). The exponential decay rate formulas for the two flavors were obtained from experimental data and the solution of the theoretical model.
[Hartungen2013] Hartungen, E., S. Juerschik, A. Jordan, A. Edtbauer, S. Feil, G. Hanel, H. Seehauser, S. Haidacher, R. Schottkowsky, L. Märk, et al., "Proton transfer reaction-mass spectrometry: fundamentals, recent advances and applications", The European Physical Journal Applied Physics, vol. 61, no. 02: Cambridge Univ Press, pp. 24303, 2013.
Link: http://journals.cambridge.org/production/action/cjoGetFulltext?fulltextid=8836242
Abstract
Proton transfer reaction-mass spectrometry (PTR-MS) offers many advantages for trace gas analysis, including no sample preparation, real-time analysis, high selectivity and sensitivity, ultra-low detection limits and very short response times. These characteristic features have made it an ideal tool for many applications in science, technology and society. Here we will discuss recent developments, in particular advances concerning sensitivity, selectivity and general applicability.
[Papurello2013] Papurello, D., A. Lanzini, E. Schufried, M. Santarelli, S. Silvestri, and F. Biasioli, "Proton Transfer Reaction-Mass Spectrometry (PTR-MS) as a rapid online tool for biogas VOCs monitoring in support of the development of Solid Oxide Fuel Cells (SOFCs)", CONFERENCE SERIES, pp. 144, 2013.
Link: http://www.ionicon.com/sites/default/files/uploads/doc/contributions_ptr_ms_Conference_6.pdf
[Lindinger2013] Lindinger, C., L. Märk, P. Sulzer, S. Juerschik, B. Agarwal, C. A. Mayhew, and T. D. Märk, "Proton-Transfer-Reaction Mass Spectrometry: Increased Selectivity in Explosives and Designer Drugs Detection", : IONICON Analytik, 2013.
Link: http://www.ionicon.com/sites/default/files/uploads/doc/poster_ionicon_pittcon_2013_explosives_and_designer_drugs_detection.pdf
[Cappellin2013] Cappellin, L., F. Loreto, E. Aprea, A. Romano, J. Sánchez { Del Pulgar}, F. Gasperi, and F. Biasioli, "PTR-MS in Italy: A Multipurpose Sensor with Applications in Environmental, Agri-Food and Health Science.", Sensors (Basel), vol. 13, no. 9: Research and Innovation Centre, Fondazione Edmund Mach (FEM), Via E. Mach 1, San Michele all'Adige 38010, Italy. francesco.loreto@cnr.it., pp. 11923–11955, 2013.
Link: http://dx.doi.org/10.3390/s130911923
Abstract
Proton Transfer Reaction Mass Spectrometry (PTR-MS) has evolved in the last decade as a fast and high sensitivity sensor for the real-time monitoring of volatile compounds. Its applications range from environmental sciences to medical sciences, from food technology to bioprocess monitoring. Italian scientists and institutions participated from the very beginning in fundamental and applied research aiming at exploiting the potentialities of this technique and providing relevant methodological advances and new fundamental indications. In this review we describe this activity on the basis of the available literature. The Italian scientific community has been active mostly in food science and technology, plant physiology and environmental studies and also pioneered the applications of the recently released PTR-ToF-MS (Proton Transfer Reaction-Time of Flight-Mass Spectrometry) in food science and in plant physiology. In the very last years new results related to bioprocess monitoring and health science have been published as well. PTR-MS data analysis, particularly in the case of the ToF based version, and the application of advanced chemometrics and data mining are also aspects characterising the activity of the Italian community.
[Liu2013] Liu, D., A. Feilberg, A. Michael Nielsen, and A. Peter S. Adamsen, "PTR-MS measurement of partition coefficients of reduced volatile sulfur compounds in liquids from biotrickling filters.", Chemosphere, vol. 90, no. 4: Dept. of Engineering, Aarhus University, Blichers Alle 20, DK-8830 Tjele, Denmark., pp. 1396–1403, Jan, 2013.
Link: http://dx.doi.org/10.1016/j.chemosphere.2012.07.068
Abstract
Biological air filtration for reduction of emissions of volatile sulfur compounds (e.g., hydrogen sulfide, methanethiol and dimethyl sulfide) from livestock production facilities is challenged by poor partitioning of these compounds into the aqueous biofilm or filter trickling water. In this study, Henry's law constants of reduced volatile sulfur compounds were measured for deionized water, biotrickling filter liquids (from the first and second stages of a two-stage biotrickling filter), and NaCl solutions by a dynamic method using Proton-Transfer-Reaction Mass Spectrometry (PTR-MS) at a temperature range of 3-45°C. NaCl solutions were used to estimate salting-out constants up to an ionic strength of 0.7 M in order to evaluate the effect of ionic strength on partitioning between air and biofilter liquids. Thermodynamic parameters (enthalpy and entropy of phase exchange) were obtained from the measured partition coefficients as a function of temperature. The results show that the partition coefficients of organic sulfur compounds in the biotrickling filter liquids were generally very close to the corresponding partition coefficients in deionized water. Based on the estimated ionic strength of biofilter liquids, it is assessed that salting-out effects are of no importance for these compounds. For H(2)S, a higher enthalpy of air-liquid partitioning was observed for 2nd stage filter liquid, but not for 1st stage filter liquid. In general, the results show that co-solute effects for sulfur compounds can be neglected in numerical biofilter models and that the uptake of volatile sulfur compounds in biotrickling filter liquids cannot be increased by decreasing ionic strength.
[Zahn2013] Zahn, A., M. Neumaier, F. Geiger, and G. Fischbeck, "PTRMS onboard passenger and research aircraft: technical realization, performance, and results", CONFERENCE SERIES, pp. 135, 2013.
Link: http://www.ionicon.com/sites/default/files/uploads/doc/contributions_ptr_ms_Conference_6.pdf
[Pennanec2013] Pennanec, X., E. Sémon, and J-L. Le Quéré, "PTR-SRI-ToF-MS analysis of aroma compounds: influence of drift tube E/N ratio on sensitivity and fragmentation", CONFERENCE SERIES, pp. 200, 2013.
Link: http://www.ionicon.com/sites/default/files/uploads/doc/contributions_ptr_ms_Conference_6.pdf
[Soukoulis2013] Soukoulis, C., L. Cappellin, E. Aprea, F. Costa, R. Viola, TD.. Märk, F. Gasperi, and F. Biasioli, "PTR-ToF-MS, A Novel, Rapid, High Sensitivity and Non-Invasive Tool to Monitor Volatile Compound Release During Fruit Post-Harvest Storage: The Case Study of Apple Ripening", Food and Bioprocess Technology, vol. 6, no. 10: Springer US, pp. 2831-2843, 2013.
Link: http://dx.doi.org/10.1007/s11947-012-0930-6
Abstract
In the present study, the potential of PTR-ToF-MS for addressing fundamental and technical post-harvest issues was tested on the non-destructive and rapid monitoring of volatile compound evolution in three apple cultivars (‘Golden Delicious’, ‘Braeburn’ and ‘Gold Rush’) during 25 days of post-harvest shelf life ripening. There were more than 800 peaks in the PTR-ToF-MS spectra of apple headspace and many of them were associated with relevant compounds. Besides the ion produced upon proton transfer, we used the ion at mass 28.031 (C2H 4 +) produced by charge transfer from residual O 2 + as a monitor for ethylene concentration. ‘Golden Delicious’ apples were characterised by higher ethylene emission rates than ‘Gold Rush’ and ‘Braeburn’, and quantitative comparison has been supported by two segment piecewise linear model fitting. Ester evolution during post-harvest ripening is strongly dependent on endogenous ethylene concentration levels. For ‘Golden Delicious’ and ‘Braeburn’, sesquiterpenes (alpha-farnesene) exhibited a fast response to ethylene emission followed by a rapid decline after the endogenous ethylene maximum peak. Carbonyl compounds displayed a different time evolution as compared to esters and terpenes and did not show any evident relationship with ethylene. Methanol and ethanol concentrations during the entire storage period did not change significantly. We show how multivariate analysis can efficiently handle the large datasets produced by PTR-ToF-MS and that the outcomes obtained are in agreement with the literature. The different volatile compounds could be simultaneously monitored with high time resolution, providing advantages over the more established techniques for the investigation of VOC dynamics in fruit post-harvest storage trials.
[Costa2013] Costa, F., L. Cappellin, E. Zini, A. Patocchi, M. Kellerhals, M. Komjanc, C. Gessler, and F. Biasioli, "QTL validation and stability for volatile organic compounds (VOCs) in apple.", Plant Sci, vol. 211: n Edmund Mach, Via Mach 1, 38010 San Michele all'Adige (TN), Italy. Electronic address: fabrizio.costa@fmach.it., pp. 1–7, Oct, 2013.
Link: http://dx.doi.org/10.1016/j.plantsci.2013.05.018
Abstract
The aroma trait in apple is a key factor for fruit quality strongly affecting the consumer appreciation, and its detection and analysis is often an extremely laborious and time consuming procedure. Molecular markers associated to this trait can to date represent a valuable selection tool to overcome these limitations. QTL mapping is the first step in the process of targeting valuable molecular markers to be employed in marker-assisted breeding programmes (MAB). However, a validation step is usually required before a newly identified molecular marker can be implemented in marker-assisted selection. In this work the position of a set of QTLs associated to volatile organic compounds (VOCs) was confirmed and validated in three different environments in Switzerland, namely Wädenswil, Conthey and Cadenazzo, where the progeny 'Fiesta×Discovery' was replicated. For both QTL identification and validation, the phenotypic data were represented by VOCs produced by mature apple fruit and assessed with a Proton Transfer Reaction-Mass Spectrometer (PTR-MS) instrument. The QTL-VOC combined analysis performed among these three locations validated the presence of important QTLs in three specific genomic regions, two located in the linkage group 2 and one in linkage group 15, respectively, for compounds related to esters (m/z 43, 61 and 131) and to the hormone ethylene (m/z 28). The QTL set presented here confirmed that in apple some compounds are highly genetically regulated and stable across environments.
[1593] Holm, E.. S., A. P. S. Adamsen, A.. Feilberg, A.. Schäfer, M.. M. Løkke, and M.. A. Petersen, "Quality changes during storage of cooked and sliced meat products measured with PTR-MS and HS-GC-MS.", Meat Sci, vol. 95, pp. 302–310, Oct, 2013.
Link: http://dx.doi.org/10.1016/j.meatsci.2013.04.046
Abstract
<p>The changes in the VOC composition of industrially produced saveloy were measured with Proton-Transfer-Reaction Mass-Spectrometry (PTR-MS) and HeadSpace Gas chromatography-mass spectrometry (HS-GC-MS) during a six weeks storage period. A decrease in the volatile organic compounds contributing to the fresh aroma of saveloy was the main change observed with both PTR-MS and HS-GC-MS. Samples of four other types of cooked and sliced meat product were measured with PTR-MS in the middle and at the end of the four week shelf-life period. These measurements showed an increase in m/z 69, 71, 87 and 89 for the pork loin and in m/z 61 for the herbal saveloy samples. These ions were assigned to the microbial spoilage markers: acetic acid, 2- and 3-methylbutanol, 2- and 3-methylbutanal, diacetyl and acetoin. Overall, this study shows that PTR-MS has potential for quality control of cooked and sliced meat products.</p>
[Morisco2013] Morisco, F., E. Aprea, V. Lembo, V. Fogliano, P. Vitaglione, G. Mazzone, L. Cappellin, F. Gasperi, S. Masone, G. Domenico { De Palma}, et al., "Rapid "breath-print" of liver cirrhosis by proton transfer reaction time-of-flight mass spectrometry. A pilot study.", PLoS One, vol. 8, no. 4: Department of Clinical Medicine and Surgery, University of Naples Federico II, Naples, Italy. filomena.morisco@unina.it, pp. e59658, 2013.
Link: http://dx.doi.org/10.1371/journal.pone.0059658
Abstract
The aim of the present work was to test the potential of Proton Transfer Reaction Time-of-Flight Mass Spectrometry (PTR-ToF-MS) in the diagnosis of liver cirrhosis and the assessment of disease severity by direct analysis of exhaled breath. Twenty-six volunteers have been enrolled in this study: 12 patients (M/F 8/4, mean age 70.5 years, min-max 42-80 years) with liver cirrhosis of different etiologies and at different severity of disease and 14 healthy subjects (M/F 5/9, mean age 52.3 years, min-max 35-77 years). Real time breath analysis was performed on fasting subjects using a buffered end-tidal on-line sampler directly coupled to a PTR-ToF-MS. Twelve volatile organic compounds (VOCs) resulted significantly differently in cirrhotic patients (CP) compared to healthy controls (CTRL): four ketones (2-butanone, 2- or 3- pentanone, C8-ketone, C9-ketone), two terpenes (monoterpene, monoterpene related), four sulphur or nitrogen compounds (sulfoxide-compound, S-compound, NS-compound, N-compound) and two alcohols (heptadienol, methanol). Seven VOCs (2-butanone, C8-ketone, a monoterpene, 2,4-heptadienol and three compounds containing N, S or NS) resulted significantly differently in compensate cirrhotic patients (Child-Pugh A; CP-A) and decompensated cirrhotic subjects (Child-Pugh B+C; CP-B+C). ROC (Receiver Operating Characteristic) analysis was performed considering three contrast groups: CP vs CTRL, CP-A vs CTRL and CP-A vs CP-B+C. In these comparisons monoterpene and N-compound showed the best diagnostic performance.Breath analysis by PTR-ToF-MS was able to distinguish cirrhotic patients from healthy subjects and to discriminate those with well compensated liver disease from those at more advanced severity stage. A breath-print of liver cirrhosis was assessed for the first time.
[Avison2013] Avison, S. J., "Real-Time Flavor Analysis: Optimization of a Proton-Transfer-Mass Spectrometer and Comparison with an Atmospheric Pressure Chemical Ionization Mass Spectrometer with an MS-Nose Interface.", J Agric Food Chem, vol. -: Firmenich S.A., Rue de la Bergère 7, Meyrin 2, CH-1217 Geneva, Switzerland., pp. -, Feb, 2013.
Link: http://dx.doi.org/10.1021/jf304418y
Abstract
Two techniques are recognized for the real-time analysis of flavors during eating and drinking, atmospheric pressure chemical ionization mass spectrometry (APCI-MS), and proton transfer reaction mass spectrometry (PTR-MS). APCI-MS was developed for the analysis of flavors and fragrances, whereas PTR-MS was originally developed and optimized for the analysis of atmospheric pollutants. Here, the suitability of the two techniques for real-time flavor analysis is compared, using a varied range of common flavor compounds. An Ionicon PTR-MS was first optimized and then its performance critically compared with that of APCI-MS. Performance was gauged using the capacity for soft ionization, dynamic linear range, and limit of detection. Optimization of the PTR-MS increased the average sensitivity by a factor of more than 3. However, even with this increase in sensitivity, the Limit of Detection was typically 10 times higher and the Dynamic Linear Range ten times narrower than that of the APCI-MS.
[Gutmann2013] Gutmann, R., M. Luchner, J. Herbig, F. Strobl, H. Armin, K. Bayer, and G. Striedner, "Realtime measurement of volatile components in the bioreactor via proton transfer reaction mass spectrometry (PTR-MS)–an approach for advanced bioprocess monitoring", 6th International PTR-MS Conference on Proton Transfer Reaction Mass Spectrometry and Its Applications, pp. 32, 2013.
Link: http://www.uibk.ac.at/iup/buch_pdfs/ptrms_2013.pdf#page=33
[Winkler2013] Winkler, K., J. Herbig, and I. Kohl, "Real-time metabolic monitoring with proton transfer reaction mass spectrometry", Journal of breath research, vol. 7, no. 3: IOP Publishing, pp. 036006, 2013.
Link: http://iopscience.iop.org/1752-7163/7/3/036006
Abstract
<p><span style="color: rgb(0, 0, 0); font-family: Arial, Helvetica, Verdana, sans-serif; font-size: 12px; line-height: 16.1875px; background-color: rgb(255, 255, 255);">We analysed the time evolution of several volatile organic compounds formed by the catabolism of ingested isotope-labelled ethanol using real-time breath gas analysis with proton-transfer-reaction mass spectrometry. Isotope labelling allowed distinguishing the emerging volatile metabolites from their naturally occurring, highly abundant counterparts in the human breath. Due to an extremely low detection limit of the employed technologies in the parts per trillion per volume range, it was possible to detect the emerging metabolic products in exhaled breath within ~10&nbsp;min after oral ingestion of isotope-labelled ethanol. We observed that ethanol was in part transformed into deuterated acetone and isoprene, reflecting the different fates of activated acetic acid (acetyl-coenzyme A), formed in ethanol metabolism. Using ethanol as a model clearly demonstrated the value of the here presented technique for the search for volatile markers for metabolic disorders in the exhaled breath and its potential usefulness in the diagnosis and monitoring of such diseases.</span></p>

Pages

Featured Articles

Download Contributions to the International Conference on Proton Transfer Reaction Mass Spectrometry and Its Applications:

 

Selected PTR-MS related Reviews

F. Biasioli, C. Yeretzian, F. Gasperi, T. D. Märk: PTR-MS monitoring of VOCs and BVOCs in food science and technology, Trends in Analytical Chemistry 30 (7) (2011).
Link

J. de Gouw, C. Warneke, T. Karl, G. Eerdekens, C. van der Veen, R. Fall: Measurement of Volatile Organic Compounds in the Earth's Atmosphere using Proton-Transfer-Reaction Mass Spectrometry. Mass Spectrometry Reviews, 26 (2007), 223-257.
Link

W. Lindinger, A. Hansel, A. Jordan: Proton-transfer-reaction mass spectrometry (PTR–MS): on-line monitoring of volatile organic compounds at pptv levels, Chem. Soc. Rev. 27 (1998), 347-375.
Link

 

Lists with PTR-MS relevant publications of the University of Innsbruck can be found here: Atmospheric and indoor air chemistry, IMR, Environmental Physics and Nano-Bio-Physics

 

Download the latest version of the IONICON publication database as BibTeX.