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Scientific Articles - PTR-MS Bibliography

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Publications

Found 3 results
Title [ Year(Asc)]
Filters: Author is Jürschik, Simone  [Clear All Filters]
2015
[1638] Lanza, M., J. W Acton, P. Sulzer, K. Breiev, S. Jürschik, A. Jordan, E. Hartungen, G. Hanel, L. Märk, T. D. Märk, et al., "Selective reagent ionisation-time of flight-mass spectrometry: a rapid technology for the novel analysis of blends of new psychoactive substances.", J Mass Spectrom, vol. 50, pp. 427–431, Feb, 2015.
Link: http://dx.doi.org/10.1002/jms.3514
Abstract
<p>In this study we demonstrate the potential of selective reagent ionisation-time of flight-mass spectrometry for the rapid and selective identification of a popular new psychoactive substance blend called &#39;synthacaine&#39;, a mixture that is supposed to imitate the sensory and intoxicating effects of cocaine. Reactions with H3O(+) result in protonated parent molecules which can be tentatively assigned to benzocaine and methiopropamine. However, by comparing the product ion branching ratios obtained at two reduced electric field values (90 and 170 Td) for two reagent ions (H3O(+) and NO(+)) to those of the pure chemicals, we show that identification is possible with a much higher level of confidence then when relying solely on the m/z of protonated parent molecules. A rapid and highly selective analytical identification of the constituents of a recreational drug is particularly crucial to medical personnel for the prompt medical treatment of overdoses, toxic effects or allergic reactions.</p>
2014
[1642] W Acton, J., M. Lanza, B. Agarwal, S. Jürschik, P. Sulzer, K. Breiev, A. Jordan, E. Hartungen, G. Hanel, L. Märk, et al., "Headspace analysis of new psychoactive substances using a Selective Reagent Ionisation-Time of Flight-Mass Spectrometer.", Int J Mass Spectrom, vol. 360, pp. 28–38, Mar, 2014.
Link: http://dx.doi.org/10.1016/j.ijms.2013.12.009
Abstract
<p>The rapid expansion in the number and use of new psychoactive substances presents a significant analytical challenge because highly sensitive instrumentation capable of detecting a broad range of chemical compounds in real-time with a low rate of false positives is required. A Selective Reagent Ionisation-Time of Flight-Mass Spectrometry (SRI-ToF-MS) instrument is capable of meeting all of these requirements. With its high mass resolution (up to m/Δm of 8000), the application of variations in reduced electric field strength (E/N) and use of different reagent ions, the ambiguity of a nominal (monoisotopic) m/z is reduced and hence the identification of chemicals in a complex chemical environment with a high level of confidence is enabled. In this study we report the use of a SRI-ToF-MS instrument to investigate the reactions of H3O(+), O2 (+), NO(+) and Kr(+) with 10 readily available (at the time of purchase) new psychoactive substances, namely 4-fluoroamphetamine, methiopropamine, ethcathinone, 4-methylethcathinone, N-ethylbuphedrone, ethylphenidate, 5-MeO-DALT, dimethocaine, 5-(2-aminopropyl)benzofuran and nitracaine. In particular, the dependence of product ion branching ratios on the reduced electric field strength for all reagent ions was investigated and is reported here. The results reported represent a significant amount of new data which will be of use for the development of drug detection techniques suitable for real world scenarios.</p>
2013
[Lanza2013] Lanza, M., J. W. Acton, S. Jürschik, P. Sulzer, K. Breiev, A. Jordan, E. Hartungen, G. Hanel, L. Märk, C. A. Mayhew, et al., "Distinguishing two isomeric mephedrone substitutes with selective reagent ionisation mass spectrometry (SRI-MS)", Journal of Mass Spectrometry, vol. 48, no. 9, pp. 1015–1018, 2013.
Link: http://dx.doi.org/10.1002/jms.3253
Abstract
The isomers 4-methylethcathinone and N-ethylbuphedrone are substitutes for the recently banned drug mephedrone. We find that with conventional proton transfer reaction mass spectrometry (PTR-MS), it is not possible to distinguish between these two isomers, because essentially for both substances, only the protonated molecules are observed at a mass-to-charge ratio of 192 (C12H18NO+). However, when utilising an advanced PTR-MS instrument that allows us to switch the reagent ions (selective reagent ionisation) from H3O+ (which is commonly used in PTR-MS) to NO+, O2+ and Kr+, characteristic product (fragment) ions are detected: C4H10N+ (72 Da) for 4-methylethcathinone and C5H12N+ (86 Da) for N-ethylbuphedrone; thus, selective reagent ionisation MS proves to be a powerful tool for fast detection and identification of these compounds. Copyright © 2013 John Wiley & Sons, Ltd.

Featured Articles

Download Contributions to the International Conference on Proton Transfer Reaction Mass Spectrometry and Its Applications:

 

Selected PTR-MS related Reviews

F. Biasioli, C. Yeretzian, F. Gasperi, T. D. Märk: PTR-MS monitoring of VOCs and BVOCs in food science and technology, Trends in Analytical Chemistry 30 (7) (2011).
Link

J. de Gouw, C. Warneke, T. Karl, G. Eerdekens, C. van der Veen, R. Fall: Measurement of Volatile Organic Compounds in the Earth's Atmosphere using Proton-Transfer-Reaction Mass Spectrometry. Mass Spectrometry Reviews, 26 (2007), 223-257.
Link

W. Lindinger, A. Hansel, A. Jordan: Proton-transfer-reaction mass spectrometry (PTR–MS): on-line monitoring of volatile organic compounds at pptv levels, Chem. Soc. Rev. 27 (1998), 347-375.
Link

 

Lists with PTR-MS relevant publications of the University of Innsbruck can be found here: Atmospheric and indoor air chemistry, IMR, Environmental Physics and Nano-Bio-Physics

 

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