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Scientific Articles - PTR-MS Bibliography

Welcome to the new IONICON scientific articles database!

Publications

Found 5 results
Title [ Year(Desc)]
Filters: Author is Dunkl, Juergen  [Clear All Filters]
2009
[Boshier2009] Boshier, P., O. Priest, J. Herbig, G. Hanna, and N. Marczin, "Influence of respiratory manoeuvres on the 'on-line' detection of volatile organic compounds (VOCs) in exhaled by hs-PTR-MS", CONFERENCE SERIES, pp. 230, 2009.
Link: http://www.ionicon.com/sites/default/files/uploads/doc/contributions_ptr_ms_Conference_4.pdf
[Herbig2009] Herbig, J., M. Seger, I. Kohl, G. Mayramhof, T. Titzmann, A. Preinfalk, K. Winkler, J. Dunkl, B. Pfeifer, C. Baumgartner, et al., "Online breath sampling with PTR-MS - A setup for large screening studies", 4th International PTR-MS Conference on Proton Transfer Reaction Mass Spectrometry and Its Applications, pp. 46, 2009.
Link: http://www.ionicon.com/sites/default/files/uploads/doc/contributions_ptr_ms_Conference_4.pdf
[Kohl2009] Kohl, I., J. Herbig, J. Beauchamp, J. Dunkl, O. Tietje, and A. Hansel, "Proton-transfer-reaction mass spectrometry online analysis of volatile organic compounds in the exhaled breath: kidney transplant rejection diagnosis", CONFERENCE SERIES, pp. 251, 2009.
Link: http://www.ionicon.com/sites/default/files/uploads/doc/contributions_ptr_ms_Conference_4.pdf#page=251
2011
[Kohl2011] Kohl, I., J. Herbig, J. Beauchamp, J. Dunkl, O. Tietje, and A. Hansel, "Online breath analysis of volatile organic compounds with PTR-MS: a guanidino breath marker for the status of uremia and kidney transplant rejection diagnosis.", 4th International PTR-MS Conference on Proton Transfer Reaction Mass Spectrometry and Its Applications, pp. 251, 2011.
Link: http://www.ionicon.com/sites/default/files/uploads/doc/contributions_ptr_ms_Conference_5.pdf
2012
[Luchner2012] Luchner, M., R. Gutmann, K. Bayer, J. Dunkl, A. Hansel, J. Herbig, W. Singer, F. Strobl, K. Winkler, and G. Striedner, "Implementation of proton transfer reaction-mass spectrometry (PTR-MS) for advanced bioprocess monitoring.", Biotechnol Bioeng, vol. 109, no. 12: ACIB GmbH, Muthgasse 11, A-1190 Vienna, Austria., pp. 3059–3069, Dec, 2012.
Link: http://dx.doi.org/10.1002/bit.24579
Abstract
We report on the implementation of proton transfer reaction-mass spectrometry (PTR-MS) technology for on-line monitoring of volatile organic compounds (VOCs) in the off-gas of bioreactors. The main part of the work was focused on the development of an interface between the bioreactor and an analyzer suitable for continuous sampling of VOCs emanating from the bioprocess. The permanently heated sampling line with an inert surface avoids condensation and interaction of volatiles during transfer to the PTR-MS. The interface is equipped with a sterile sinter filter unit directly connected to the bioreactor headspace, a condensate trap, and a series of valves allowing for dilution of the headspace gas, in-process calibration, and multiport operation. To assess the aptitude of the entire system, a case study was conducted comprising three identical cultivations with a recombinant E. coli strain, and the volatiles produced in the course of the experiments were monitored with the PTR-MS. The high reproducibility of the measurements proved that the established sampling interface allows for reproducible transfer of volatiles from the headspace to the PTR-MS analyzer. The set of volatile compounds monitored comprises metabolites of different pathways with diverse functions in cell physiology but also volatiles from the process matrix. The trends of individual compounds showed diverse patterns. The recorded signal levels covered a dynamic range of more than five orders of magnitude. It was possible to assign specific volatile compounds to distinctive events in the bioprocess. The presented results clearly show that PTR-MS was successfully implemented as a powerful bioprocess-monitoring tool and that access to volatiles emitted by the cells opens promising perspectives in terms of advanced process control.

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Selected PTR-MS related Reviews

F. Biasioli, C. Yeretzian, F. Gasperi, T. D. Märk: PTR-MS monitoring of VOCs and BVOCs in food science and technology, Trends in Analytical Chemistry 30 (7) (2011).
Link

J. de Gouw, C. Warneke, T. Karl, G. Eerdekens, C. van der Veen, R. Fall: Measurement of Volatile Organic Compounds in the Earth's Atmosphere using Proton-Transfer-Reaction Mass Spectrometry. Mass Spectrometry Reviews, 26 (2007), 223-257.
Link

W. Lindinger, A. Hansel, A. Jordan: Proton-transfer-reaction mass spectrometry (PTR–MS): on-line monitoring of volatile organic compounds at pptv levels, Chem. Soc. Rev. 27 (1998), 347-375.
Link

 

Lists with PTR-MS relevant publications of the University of Innsbruck can be found here: Atmospheric and indoor air chemistry, IMR, Environmental Physics and Nano-Bio-Physics

 

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