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Scientific Articles - PTR-MS Bibliography

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Publications

Found 3 results
Title [ Year(Asc)]
Filters: Author is Anton Amann  [Clear All Filters]
2013
[Kohl2013] Kohl, I., J. Herbig, J. Dunkl, A. Hansel, M. Daniaux, and M. Hubalek, "Chapter 6 - Smokers Breath as Seen by Proton-Transfer-Reaction Time-of-Flight Mass Spectrometry (PTR-TOF-MS)", Volatile Biomarkers, Boston, Elsevier, pp. 89 - 116, 2013.
Link: http://www.sciencedirect.com/science/article/pii/B9780444626134000064
Abstract
Abstract Proton-transfer-reaction time-of-flight mass spectrometry has been employed in a 12 months breath gas analysis study to describe the breath composition of 19 cigarette smoking and 53 non-smoking women. The most prevalent constituents were acetone (1.8 ppmv), methanol (310 ppbv), isoprene (280 ppbv), ethanol (130 ppbv), acetaldehyde (90 ppbv) and acetic acid (70 ppbv). Smokers showed the largest signal increase in acetonitrile (ratio smoker/non-smoker 29), benzene (ratio 11), 2-methylfuran (ratio 8) and 2,5-dimethylfuran (ratio 7). Calibration gas measurements allowed the instruments performance regarding precision and accuracy of ion mass-to-charge, m/z, and concentration accuracy measurement to be assessed. The standard deviation of the concentration measurements was 14% or smaller (with the exception of ethanol) with no trend in this variation of sensitivity. The limit of detection (LOD) lay in the sub ppbv range, based on an integration time of 2 s. The m/z accuracy was better than 0.0016 (or less than 29 ppm of the ion mass) throughout the study. The standard deviation of the measured m/z was less than 0.0025 and the coefficient of variation was less than 29 ppm. Keywords PTR-TOF-MS, Smokers’ breath, Breath volatile organic compounds, \{VOCs\}
2007
[Wehinger2007] Wehinger, A., A. Schmid, S. Mechtcheriakov, M. Ledochowski, C. Grabmer, G. A. Gastl, and A. Amann, "Lung cancer detection by proton transfer reaction mass-spectrometric analysis of human breath gas", International Journal of Mass Spectrometry, vol. 265, no. 1, pp. 49 - 59, 2007.
Link: http://www.sciencedirect.com/science/article/pii/S1387380607002382
Abstract
Background: Determination of the diagnostic usefulness of proton transfer reaction mass spectrometry (PTR-MS) for detecting primary lung cancer through analysis of volatile organic compounds (VOCs) in exhaled human breath was demonstrated in this investigation. Unlike, for example, gas-chromatographic analyses, PTR-MS can be used without time-consuming preconcentration of the gas samples.
2004
[Amann2004] Amann, A., G. Poupart, S. Telser, M. Ledochowski, A. Schmid, and S. Mechtcheriakov, "Applications of breath gas analysis in medicine", International Journal of Mass Spectrometry, vol. 239, no. 2-3, pp. 227 - 233, 2004.
Link: http://www.sciencedirect.com/science/article/pii/S1387380604003574
Abstract
Volatile organic compounds (VOCs) in exhaled breath gas provide valuable information about the subjects' physiological and pathophysiological condition. Proton-transfer-reaction mass spectrometry (PTR-MS) allows rapid and online measurements of these substances. We present results of three studies illustrating the potential of breath gas analysis by PTR-MS in various contexts: long-time online monitoring of VOCs in sleeping subjects suggests that VOC profiles are related to sleep stages. Analysis of VOC concentrations in the breath of carbohydrate malabsorbers emphasizes the role played by bacteria in the gut. Finally, we demonstrate the large intra- and intersubject concentration variability of VOCs by considering one particular mass.

Featured Articles

Download Contributions to the International Conference on Proton Transfer Reaction Mass Spectrometry and Its Applications:

 

Selected PTR-MS related Reviews

F. Biasioli, C. Yeretzian, F. Gasperi, T. D. Märk: PTR-MS monitoring of VOCs and BVOCs in food science and technology, Trends in Analytical Chemistry 30 (7) (2011).
Link

J. de Gouw, C. Warneke, T. Karl, G. Eerdekens, C. van der Veen, R. Fall: Measurement of Volatile Organic Compounds in the Earth's Atmosphere using Proton-Transfer-Reaction Mass Spectrometry. Mass Spectrometry Reviews, 26 (2007), 223-257.
Link

W. Lindinger, A. Hansel, A. Jordan: Proton-transfer-reaction mass spectrometry (PTR–MS): on-line monitoring of volatile organic compounds at pptv levels, Chem. Soc. Rev. 27 (1998), 347-375.
Link

 

Lists with PTR-MS relevant publications of the University of Innsbruck can be found here: Atmospheric and indoor air chemistry, IMR, Environmental Physics and Nano-Bio-Physics

 

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